The keratoconus conundrum:the inflammatory – environmental interplay
Keratoconus is an ectatic corneal disorder, first described by Dr John Nottingham in 1854 in his treatise entitled ‘Practical observations on the conical cornea and on the short sight and other defects of vision connected with it’. His observations were further supported by other ophthalmologists conducting research in the field, such as Sir William Bowman.
Nevertheless, 167 years later and keratoconus pathophysiology and associations remain a mystery and a challenge for researchers.